abstract：CONTEXT:Pediatric myelodysplastic syndromes (MDSs) are uncommon disorders, which may be difficult to diagnose, particularly in the absence of increased blasts. Pediatric MDSs have several unique features including their association with inherited/constitutional disorders in approximately one third of patients. The clas...

journal_title：Archives of pathology & laboratory medicine

authors： Elghetany MT

更新日期：2007-07-01 00:00:00

abstract：CONTEXT:CpG island hypermethylation is attracting attention because of its importance as a tumor marker and its potential mechanism for the development of human cancers. Extrahepatic cholangiocarcinoma has been poorly investigated with respect to CpG island hypermethylation, and the number of genes known to be methylat...

journal_title：Archives of pathology & laboratory medicine

authors： Kim BH,Cho NY,Choi M,Lee S,Jang JJ,Kang GH

更新日期：2007-06-01 00:00:00

abstract：:Sclerosing angiomatoid nodular transformation (SANT) is a recently recognized nonneoplastic vascular lesion of the spleen with fewer than 30 cases described. Microscopically, SANT consists of multiple well-circumscribed vascular/angiomatoid nodules showing plump endothelial cell and extravasated erythrocytes. The nodu...

journal_title：Archives of pathology & laboratory medicine

authors： Awamleh AA,Perez-Ordoñez B

更新日期：2007-06-01 00:00:00

abstract：CONTEXT:Flow cytometric immunophenotyping is a useful ancillary tool in the diagnosis and subclassification of acute myeloid leukemias (AMLs). A recent study concluded that CD64 is sensitive and specific for distinguishing AMLs with a monocytic component (ie, AML M4 and AML M5) from other AML subtypes. However, in that...

journal_title：Archives of pathology & laboratory medicine

authors： Dunphy CH,Tang W

更新日期：2007-05-01 00:00:00

abstract：:Human parvovirus B19 is a single-stranded DNA virus with a predilection for infecting rapidly dividing cell lines, such as bone marrow erythroid progenitor cells. People with defective cell-mediated immunity (eg, severe combined immunodeficiency syndrome; acquired immunodeficiency syndrome; and patients receiving immu...

journal_title：Archives of pathology & laboratory medicine

authors： Florea AV,Ionescu DN,Melhem MF

更新日期：2007-05-01 00:00:00

abstract：CONTEXT:The pathogenesis of respiratory epithelial adenomatoid hamartoma (REAH) and inverted papilloma (IP) is poorly understood, especially compared with sinonasal adenocarcinoma (SNAC). One feature of malignant glandular lesions is loss of the basal/myoepithelial layer. The immunophenotype of the basal/myoepithelial ...

journal_title：Archives of pathology & laboratory medicine

authors： Ozolek JA,Barnes EL,Hunt JL

更新日期：2007-04-01 00:00:00

abstract：CONTEXT:Mucin 4 (MUC4) is a high-molecular-weight membrane-bound glycoprotein that is expressed in the foregut before epithelial differentiation. It is found in normal adult airway epithelium, non-small cell lung carcinoma (NSCLC) and in other human malignancies independent of mucus secretion. Although its tissue distr...

journal_title：Archives of pathology & laboratory medicine

authors： Kwon KY,Ro JY,Singhal N,Killen DE,Sienko A,Allen TC,Zander DS,Barrios R,Haque A,Cagle PT

更新日期：2007-04-01 00:00:00

abstract：:Desmoplastic small round cell tumor typically presents with abundant desmoplastic stroma containing nested primitive round cells bearing a polyphenotypic immunohistochemical profile. Lesions with minimal classic morphology pose a formidable diagnostic challenge. The current case represents one such example, arising as...

journal_title：Archives of pathology & laboratory medicine

authors： Zhang J,Dalton J,Fuller C

更新日期：2007-04-01 00:00:00

abstract：CONTEXT:Endometrial tissue specimens are commonly encountered in daily practice. It is well known that a number of problematic diagnostic scenarios occur relative to these specimens. OBJECTIVE:To emphasize practical aspects of endometrial specimen handling and reporting, with selected comments on common diagnostic pit...

journal_title：Archives of pathology & laboratory medicine

authors： Silverberg SG

更新日期：2007-03-01 00:00:00

abstract：CONTEXT:Despite the widespread practice of pathologist review of blood and body fluid smears, little is known about its impact on improving patient care. OBJECTIVE:To assess the clinical usefulness of pathologist review of blood and body fluid smears. DESIGN:Survey study. Pathology residents contacted the ordering ph...

journal_title：Archives of pathology & laboratory medicine

authors： Sandhaus LM,Wald DN,Sauder KJ,Steele EL,Meyerson HJ

更新日期：2007-03-01 00:00:00

abstract：CONTEXT:Radiologic studies are obtained for diagnostic and treatment planning purposes in the evaluation of patients with intracranial neoplasms. These studies are discussed at radiology/pathology working conferences and are often beneficial in the analysis of pathologic specimens for tissue diagnosis. Therefore, clini...

journal_title：Archives of pathology & laboratory medicine

authors： Debnam JM,Ketonen L,Hamberg LM,Hunter GJ

更新日期：2007-02-01 00:00:00

abstract：:Leydig cell tumor (LCT) is a rare tumor of the male testicular interstitium. This article provides an overview of the major pathologic manifestations of LCT of the testis; patient characteristics; clinical, radiologic, and laboratory features; prognosis; and management. LCTs of the testis are frequently hormonally act...

journal_title：Archives of pathology & laboratory medicine

authors： Al-Agha OM,Axiotis CA

更新日期：2007-02-01 00:00:00

abstract：CONTEXT:Because of a marked increase in the number of requests for antinuclear antibodies, anti-extractable nuclear antigen antibodies, and anti-double-stranded DNA antibodies for the diagnosis of autoimmune rheumatic disease, guidelines have been proposed for their appropriate use. OBJECTIVE:To evaluate in terms of c...

journal_title：Archives of pathology & laboratory medicine

authors： Tampoia M,Brescia V,Fontana A,Zucano A,Morrone LF,Pansini N

更新日期：2007-01-01 00:00:00

abstract：CONTEXT:Case reports have described detection of candidemia by examination of peripheral blood smears. It is unclear whether this method has wider applicability for early detection of fungemia. OBJECTIVE:To determine the sensitivity of smear review for detecting candidemia. DESIGN:Normal and cytopenic blood was spike...

journal_title：Archives of pathology & laboratory medicine

authors： Branda JA,Ferraro MJ,Kratz A

更新日期：2007-01-01 00:00:00

abstract：CONTEXT:Childhood mortality statistics are based on death certificates. The causes of death listed on death certificates may not be confirmed by autopsy findings, and mortality statistics may reflect deaths of many children with chronic disease. The diseases responsible for nontraumatic deaths of previously healthy chi...

journal_title：Archives of pathology & laboratory medicine

authors： Taggart MW,Craver R

更新日期：2006-12-01 00:00:00

abstract：CONTEXT:Foreign material typically elicits reactions dominated by multinucleated giant cells. Pulse granulomas are peculiar reactions to particles of food that are characterized by clusters of small to medium-sized hyaline rings. Pulse granulomas are rare and have occupied only the lungs, in association with aspiration...

journal_title：Archives of pathology & laboratory medicine

authors： Rhee DD,Wu ML

更新日期：2006-12-01 00:00:00

abstract：CONTEXT:Clear cell chondrosarcoma (CCC) is commonly considered to be a low-grade subtype of chondrosarcoma. However, a few cases of CCC behave as high-grade lesions (with early metastases or multiple/synchronous locations). OBJECTIVE:To investigate morphologic features that can help predict the aggressiveness of these...

journal_title：Archives of pathology & laboratory medicine

authors： Corradi D,Bacchini P,Campanini N,Bertoni F

更新日期：2006-11-01 00:00:00

abstract：:Krukenberg tumor is an uncommon metastatic tumor of the ovary. This article provides an overview of the major pathologic manifestations of Krukenberg tumor, patient characteristics, clinical and laboratory features of the disease, prognostic factors, and current knowledge about its pathogenesis. Pathologists have to b...

journal_title：Archives of pathology & laboratory medicine

authors： Al-Agha OM,Nicastri AD

更新日期：2006-11-01 00:00:00

abstract：CONTEXT:Antibody-mediated humoral rejection in kidney and heart allografts is well recognized and is often associated with poor outcome. C4d deposition in allograft biopsy specimens occurs at sites of antibody-mediated complement activation and has become one of the histopathologic criteria for diagnosis of humoral rej...

journal_title：Archives of pathology & laboratory medicine

authors： Troxell ML,Higgins JP,Kambham N

更新日期：2006-10-01 00:00:00

abstract：:We report a case of hepatic inflammatory myofibroblastic tumor in a 26-year-old African American man who presented with right upper quadrant pain, weight loss, and fatigue during the previous year. Hepatomegaly was found on physical examination. Laboratory findings were significant for mild normocytic, normochromic an...

journal_title：Archives of pathology & laboratory medicine

authors： Solomon GJ,Kinkhabwala MM,Akhtar M

更新日期：2006-10-01 00:00:00

abstract：CONTEXT:The Mre11-Rad50-NBS1 complex plays an important role in telomere maintenance. Recently, it has been proposed that alterations in Mre11 function may be contributing factors in the development of some tumors. Moreover, mutations of Mre11 have been demonstrated to cause reduced Mre11 immunostaining. OBJECTIVE:To ...

journal_title：Archives of pathology & laboratory medicine

authors： Nakanishi K,Kumaki F,Hiroi S,Mukai M,Ikeda E,Kawai T

更新日期：2006-09-01 00:00:00

abstract：CONTEXT:Current regulatory proficiency testing scoring results in an automatic failure for identifying high-grade squamous intraepithelial lesion (HSIL) as negative. OBJECTIVE:The College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology data from January 2004 to April 2005 were an...

journal_title：Archives of pathology & laboratory medicine

authors： College of American Pathologists.,Young NA,Moriarty AT,Walsh MK,Wang E,Wilbur DC

更新日期：2006-08-01 00:00:00

abstract：CONTEXT:Angiosarcomas are rare malignancies that commonly arise in the head and neck. No definitive precursor lesion or etiological link between hemangiomas and angiosarcoma has been postulated. Evidence at the cell culture level suggests that loss of heterozygosity of 13q might be involved in tumorigenesis of endothel...

journal_title：Archives of pathology & laboratory medicine

authors： Domfeh AB,Fichera M,Hunt JL

更新日期：2006-08-01 00:00:00

abstract：:We report the case of a patient treated with a combination of fludarabine and cyclophosphamide after suffering from B-cell chronic lymphocytic leukemia for 10 years. Three months after treatment, the patient presented with an unusual association, not previously reported in the literature: Richter syndrome (monotypic E...

journal_title：Archives of pathology & laboratory medicine

authors： Compérat E,Delmer A,Le Tourneau A,Molina TJ,Diebold J,Audouin J

更新日期：2006-08-01 00:00:00

abstract：CONTEXT:Laboratory data are essential to the medical care of fetuses, infants, children, and adolescents. However, the performance and interpretation of laboratory tests on specimens from these patients, which may constitute a significant component of the workload in general hospitals and integrated health care systems...

journal_title：Archives of pathology & laboratory medicine

authors： Pysher TJ,Bach PR,Geaghan SM,Hamilton MS,Laposata M,Lockitch G,Brugnara C,Coffin CM,Pasquali M,Rinaldo P,Roberts WL,Rutledge JC,Ashwood ER,Blaylock RC,Campos JM,Goldsmith B,Jones PM,Lim M,Meikle AW,Perkins SL,Perr

更新日期：2006-07-01 00:00:00

abstract：:Secretory breast carcinoma is a rare breast cancer. It occurs in all age groups, with the majority of patients being adults. It is a rare occurrence in elderly (>50 years) patients; only 5 cases have been reported in this patient group in the English literature. It is even rarer in males, with only 15 cases reported i...

journal_title：Archives of pathology & laboratory medicine

authors： Yaqoob N,Kayani N,ul Hasan SH

更新日期：2006-07-01 00:00:00

abstract：:Pulmonary adenocarcinoma is one of the most common types of lung cancer. Traditionally, adenocarcinomas have been divided based on their degree of resemblance to their parent tissues into 3 histopathologic types: well, moderately, and poorly differentiated. In the majority of cases, this schema is sufficient to catego...

journal_title：Archives of pathology & laboratory medicine

authors： Moran CA

更新日期：2006-07-01 00:00:00

abstract：CONTEXT:Signet-ring cell carcinoma (SRCC) is a poorly differentiated mucin-producing adenocarcinoma that may arise from many different organs, but all SRCCs share identical morphology. It is not possible to differentiate sites of origin for metastatic SRCC based on morphology alone. Mucins are high-molecular-weight gly...

journal_title：Archives of pathology & laboratory medicine

authors： Nguyen MD,Plasil B,Wen P,Frankel WL

更新日期：2006-06-01 00:00:00

abstract：:Renal solitary fibrous tumors (SFTs) have been reported infrequently. We report a 76-year-old man with a left renal mass that had previously been shown radiographically to be stable, but was now growing. Grossly, the mass measured 12 cm, was poorly circumscribed, and invaded beyond the renal capsule. Approximately 10%...

journal_title：Archives of pathology & laboratory medicine

authors： Fine SW,McCarthy DM,Chan TY,Epstein JI,Argani P

更新日期：2006-06-01 00:00:00

abstract：CONTEXT:Although much has been said and written about medical error and about error in pathology since the publication of the Institute of Medicine's report on medical error in 1999, precise definitions of what constitutes error in anatomic pathology do not exist for the specialty. Without better definitions, it is imp...

journal_title：Archives of pathology & laboratory medicine

authors： Sirota RL

更新日期：2006-05-01 00:00:00

abstract：:Critical values in anatomic pathology are usually information sensitive, whereas most such values in laboratory medicine are time sensitive. However, there is an important time element in anatomic pathology as well. Pathologists should be aware that many medicolegal actions against radiologists are based on failure to...

journal_title：Archives of pathology & laboratory medicine

authors： LiVolsi VA,Leung S

更新日期：2006-05-01 00:00:00

abstract：CONTEXT:Inflicted traumatic brain injury of infants and young children results in a complex array of autopsy findings. In many cases, immunostains for beta-amyloid precursor protein are used to detect axonal injury. Interpretation of the gross, microscopic, and immunostaining results requires the integration of the man...

journal_title：Archives of pathology & laboratory medicine

authors： Dolinak D,Reichard R

更新日期：2006-05-01 00:00:00

abstract：CONTEXT:Correct diagnosis of the tissue origin of a metastatic cancer is the first step in disease management, but it is frequently difficult using standard pathologic methods. Microarray-based gene expression profiling has shown great promise as a new tool to address this challenge. OBJECTIVE:Adoption of microarray t...

journal_title：Archives of pathology & laboratory medicine

authors： Ma XJ,Patel R,Wang X,Salunga R,Murage J,Desai R,Tuggle JT,Wang W,Chu S,Stecker K,Raja R,Robin H,Moore M,Baunoch D,Sgroi D,Erlander M

更新日期：2006-04-01 00:00:00

abstract：:Tumoral calcinosis is a rare ectopic calcification syndrome characterized by irregular soft tissue masses originally described as being found mainly in large joints. We report 3 cases of tumoral calcinosis that occurred in unusual locations, the metacarpophalageal and proximal interphalangeal joints of the hand. The p...

journal_title：Archives of pathology & laboratory medicine

authors： Kim HS,Suh JS,Kim YH,Park SH

更新日期：2006-04-01 00:00:00

abstract：CONTEXT:The practice of gynecologic cytology requires that high-grade squamous intraepithelial lesion (HSIL) be precisely recognized. In this regard, hyperchromatic crowded groups are known to be difficult to classify in conventional gynecologic cytology, but whether this is true in ThinPrep specimens is uncertain. OB...

journal_title：Archives of pathology & laboratory medicine

authors： Renshaw AA,Mody DR,Wang E,Haja J,Colgan TJ,Cytopathology Resource Committee, College of American Pathologists.

更新日期：2006-03-01 00:00:00

abstract：:Heterologous differentiation in osteosarcoma is rare, with only 17 cases previously described in the literature. We report a case of a mandibular osteoblastic osteosarcoma with rhabdomyosarcomatous differentiation in a 45-year-old man who had a history of Hodgkin lymphoma that was treated with chemotherapy and radiati...

journal_title：Archives of pathology & laboratory medicine

authors： Seethala RR,Sturgis EM,Raymond AK,Deavers MT

更新日期：2006-03-01 00:00:00

abstract：CONTEXT:Accreditation Council for Graduate Medical Education guidelines require the evaluation of residents in 6 competencies. Pathology residents demonstrate medical knowledge, patient care, communication, and practice-based learning competencies in their attainment of competency in surgical pathology diagnosis. OBJE...

journal_title：Archives of pathology & laboratory medicine

authors： Ducatman BS,Ducatman AM

更新日期：2006-02-01 00:00:00

abstract：CONTEXT:Autopsy continues to provide important data for quality assurance, teaching, scientific purposes, and health planning, especially if performed according to a comprehensive protocol. OBJECTIVE:To describe and analyze data from all perinatal and pediatric autopsies performed at a university hospital in Brazil. ...

journal_title：Archives of pathology & laboratory medicine

authors： Peres LC

更新日期：2006-01-01 00:00:00

abstract：CONTEXT:Preoperative fine-needle aspiration of thyroid lesions has greatly diminished the need for surgical evaluation. However, because thyroid nodules are common lesions, many still require surgical intervention and represent a substantial number of cases that the pathologist encounters in the frozen section laborato...

journal_title：Archives of pathology & laboratory medicine

authors： Anton RC,Wheeler TM

更新日期：2005-12-01 00:00:00

abstract：CONTEXT:The correctly completed death certificate provides invaluable personal, epidemiologic, and legal information and should be thorough and accurate. Death certification errors are common and range from minor to severe. OBJECTIVE:To determine the frequency and type of errors by nonpathologist physicians at a unive...

journal_title：Archives of pathology & laboratory medicine

authors： Pritt BS,Hardin NJ,Richmond JA,Shapiro SL

更新日期：2005-11-01 00:00:00